PHB2 promotes SHIP2 ubiquitination via the E3 ligase NEDD4 to regulate AKT signaling in gastric cancer.

"Declarations Ethics approval and consent to participateStudies using human tissues were approved by the Human Ethics Review Committee of Anhui Medical University (20190328), and all patients provided written informed consent before the commencement of the research. The study was conducted following ethical principles outlined in the Declaration of Helsinki, and compliant with all relevant ethical regulations for human research. Consent for publicationAll authors consent to the publication. Competing interestsThe authors state no conflict of interest. Competing interests The authors state no conflict of interest."

"Funding This work was supported by the National Natural Science Foundation of China (No. 81972264) and the Anhui Provincial Natural Science Foundation (No. 2008085MH258)."