Cocaine regulates antiretroviral therapy CNS access through pregnane-x receptor-mediated drug transporter and metabolizing enzyme modulation at the blood brain barrier.

"Declarations Ethics approval and consent to participateNot applicable. Consent for publicationNot applicable. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding Research reported in this publication was supported by the National Institutes of Health under award number R00 DA044838 (DWW), R01 DA052859 (DWW), and U01 DA058527 (DWW), R01 GM103853 (BCO), and R01 AG064908 (BCO). Additionally, HNW was supported by T32 GM144272 granted to the Biochemistry, Cellular & Molecular Biology Graduate Program at Johns Hopkins and AM was supported by R25 GM109441 granted to the Post-baccalaureate Research Education Program at Johns Hopkins. This work was supported, in part, by pilot funding provided by parent funding under the JHU NIMH Center for Novel Therapeutics for HIV-associated Cognitive Disorders P30 MH075673 to Justin C. McArthur. The authors also acknowledge mentorship to DWW from the Johns Hopkins University Center for AIDS Research (P30 AI094189). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health."