The evolution of constitutively active humoral immune defenses in Drosophila populations under high parasite pressure.

"plos publication stage vor-update-to-uncorrected-proof publication update 2024-01-24 data availability the rnaseq data has been submitted to the ncbi sequence read archive under the bioproject number prjna1020111 with biosample accessions from samn37513352 to samn37513387.; data availability the rnaseq data has been submitted to the ncbi sequence read archive under the bioproject number prjna1020111 with biosample accessions from samn37513352 to samn37513387.; the raw rnaseq reads from this independent study were deposited in the ncbi sequence read archive under the bioproject number prjna1021619. file s1 table sample names are indicated as population_time point_treatment (csv data availability the rnaseq data has been submitted to the ncbi sequence read archive under the bioproject number prjna1020111"

"The authors have declared that no competing interests exist."

"This work was funded by the following grants awarded to Francis M. Jiggins: Leverhulme Trust grant (RPG-2020-236), Natural Environment Research Council grant (NE/P00184X/1), and Biotechnology and Biological Sciences Research Council (BBSRC) grant (BB/V000667/1). Shuyu O. Zhou receives a student stipend from the Gates Cambridge Trust. Ramesh Arunkumar receives a salary from a Peter and Traudl Engelhorn Stiftung postdoctoral fellowship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."