Dynamic multilayer functional connectivity detects preclinical and clinical Alzheimer's disease.

"Conflict of interest statement : None declared."

"Funding This work was supported by the Swedish Research Council (#2018-02201; #2022-01108) [to J.B.P.], The Center for Medical Innovation (#20200695) [to J.B.P.], the Swedish Alzheimer Foundation (#AF-968323) [to J.B.P.], a Senior Researcher Position Karolinska Institute grant [to J.B.P.], the Swedish Brain Foundation (FO2022-0147) [to J.B.P.], Gamla Tjänarinnor (#2020-01016; #2021-01207; #2022-01341) [to A.C.G., J.B.P.], KI foundations [to J.B.P.], and Stohnes [to A.C.G., J.B.P.]. Data used in the preparation of this article were obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Data collection and sharing of ADNI was funded by the National Institutes of Health Grant U01 AG024904 and Department of Defense award number W81XWH-12-2-0012. ADNI is funded by the National Institute on Aging, the National Institute of Biomedical Imaging and Bioengineering, and through generous contributions from the following: Alzheimer’s Association; Alzheimer’s Drug Discovery Foundation; BioClinica, Inc.; Biogen Idec Inc.; Bristol-Myers Squibb Company; Eisai Inc.; Elan Pharmaceuticals, Inc.; Eli Lilly and Company; F. Hoffmann-LaRoche Ltd and its affiliated company Genentech, Inc.; GEHealthcare; Innogenetics, N.V.; IXICO Ltd; Janssen Alzheimer Immunotherapy Research & Development, LLC.; Johnson & Johnson Pharmaceutical Research & Development LLC.; Medpace, Inc.; Merck & Co., Inc.; Meso Scale Diagnostics, LLC.; NeuroRx Research; Novartis Pharmaceuticals Corporation; Pfizer Inc.; Piramal Imaging; Servier; Synarc Inc.; and Takeda Pharmaceutical Company. The Canadian Institutes of Health Research is providing funds to support ADNI clinical sites in Canada. Private sector contributions are facilitated by the Foundation for the National Institutes of Health (www.fnih.org). The grantee organization is the Northern California Institute for Research and Education, and the study is coordinated by the Alzheimer’s Disease Cooperative Study at the University of California, San Diego. ADNI data are disseminated by the Laboratory for Neuro Imaging at the University of California, Los Angeles. Conflict of interest statement: None declared."