Personalizing the first dose of FSH for IVF/ICSI patients through machine learning: a non-inferiority study protocol for a multi-center randomized controlled trial.

"Declarations Ethics approval and consent to participate {24}Permission to conduct this study was obtained from the Ethical Committee for Research of Eugin on 8 March 2023 (approval code: ALGO3). Written informed consent will be obtained from all participants prior to inclusion. Consent for publication {32}Written informed consent will be obtained from all participants prior to inclusion in the trial. A model consent form can be provided upon request. Competing interests {28}The authors declare that they have no competing interests. Competing interests {28} The authors declare that they have no competing interests."

"Funding {4} Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. To date, no specific grant from any funding agency in the public, commercial, or not-for-profit sectors has been received for the execution of this trial. Nuria Correa is supported by Doctorat Industrial funded by Generalitat de Catalunya [DI-2019-24], by project CI-SUSTAIN funded by the Spanish Ministry of Science and Innovation [PID2019-104156GB-I00], and by intramural funding by Clinica Eugin-Eugin Group that supported the design of the study."

"Trial registration ClinicalTrials.gov, NCT05948293. Registered on 14 July 2023."