Associations between genetically predicted plasma protein levels and Alzheimer's disease risk: a study using genetic prediction models.

"for the interval somalogic study the individual-level genotype and protein data and full summary association results from the genetic analysis are available through the european genotype archive (accession number egas00001002555). availability of data and materials summary statistics of the gwas meta-analysis of ad risk by bellenguez et al are available at gwas catalog ( https://www ebi ac uk/gwas/ ) under accession no gcst90027158"

"the scripts and protein genetic prediction models are available at https://github com/arthur1021/protein-prediction-models ."

"Declarations Ethics approval and consent to participateThis study was approved by the University of Hawaii Institutional Review Board (2019–00402). Consent for publicationNot applicable. Competing interestsL.W. provided consulting service to Pupil Bio Inc. and received honorarium. No potential conflicts of interest were disclosed by other authors. Competing interests L.W. provided consulting service to Pupil Bio Inc. and received honorarium. No potential conflicts of interest were disclosed by other authors. "

"Funding This research is supported by University of Hawaii Cancer Center and Florida State University. L.W. is also supported by U54 HG013243. Keenan Walker was supported by the Intramural Research Program of the National Institutes of Health (National Institute on Aging)."