The impact of PA/I38 substitutions and PA polymorphisms on the susceptibility of zoonotic influenza A viruses to baloxavir.

"Declarations Ethics statementAll experiments were authorized by the Biosafety Management Committee on Pathogens and Other Hazardous Agents and the Safety Committee on Genetic Recombination Experiments, Hokkaido University. Regarding dual-use experiments, we have described the experiment plan, the progress of the experiment, and its safety assurance, and we have received approval for the contents from this committee. Conflicts of interestK.T., T.N., S.O., A.S., T.S., and A.N. are employees of Shionogi & Co., Ltd. K.M., M.O., Y.S., and H.K. received financial support from Shionogi & Co., Ltd. for the studies reported in this article. Shionogi & Co., Ltd. financially supported all work related to this study. Conflicts of interest K.T., T.N., S.O., A.S., T.S., and A.N. are employees of Shionogi & Co., Ltd. K.M., M.O., Y.S., and H.K. received financial support from Shionogi & Co., Ltd. for the studies reported in this article. Shionogi & Co., Ltd. financially supported all work related to this study."

"Funding All experiments were funded by Shionogi and Co., Ltd. This research received no external funding."