ADAM8 silencing suppresses the migration and invasion of fibroblast-like synoviocytes via FSCN1/MAPK cascade in osteoarthritis.

"Declarations Ethics approval and consent to participateAll animal experiments and tests were guided and approved by the Ethics Committee of the Soochow University. Consent for publicationNot applicable. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding This work was supported by the National Natural Science Foundation of China (82072425, 82072498, 82272657), the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD), Jiangsu Medical Research Project (ZD2022014), the Program of Jiangsu science and technology Department (BE2021650, BE2022737), National and Local Engineering Laboratory of New Functional Polymer Materials (SDGC2205) and the Program of Suzhou Health Commission (GSWS2022002, SZXK202111)."