Integrating UHPLC-MS/MS quantitative analysis and exogenous purine supplementation to elucidate the antidepressant mechanism of Chaigui granules by regulating purine metabolism.

"Declaration of competing interest The authors declare that there are no conflicts of interest."

"This work was financially supported by the 10.13039/501100001809National Natural Science Foundation of China (Grant Nos.: 82074323 and 81673572), 10.13039/501100013317Key Research and Development Program of Shanxi Province (Grant No.: 202102130501010), Innovation Project for Graduate Students in Shanxi Province (Grant No.: 2022Y162), the Major Science and Technology Project for “Significant New Drugs Creation” (Grant No.: 2017ZX09301047), and Research Project Supported by 10.13039/501100003398Shanxi Scholarship Council of China (Grant No.: 2020019). Jiajun Chen: Methodology, Investigation, Validation, Writing - Original draft preparation, Reviewing and Editing; Tian Li: Methodology, Investigation, Writing - Original draft preparation; Dehua Huang: Investigation; Wenxia Gong, Junsheng Tian, Xiaoxia Gao, Xuemei Qin, and Guanhua Du: Supervision; Yuzhi Zhou: Funding acquisition, Methodology, Supervision, Writing - Reviewing and Editing."