Glutaredoxin-1 alleviates acetaminophen-induced liver injury by decreasing its toxic metabolites.

"Declaration of competing interest The authors declare that there are no conflicts of interest."

"This study was supported by the 10.13039/501100001809National Natural Science Foundation of China (Grant Nos.: 82025007, 81930020, and 82170874) and 10.13039/501100002858China Postdoctoral Science Foundation (Grant No.: 2022M710099). We appreciate professor Yao Chen and Jing Guo (Department of Clinical Pharmacology, 10.13039/501100011790Xiangya Hospital, Central South University) for their experimental supports, and Qianlun Pu (Advance Mass Spectrometry Center, West China hospital, Sichuan University) for the technical support. Ying Xu: Conceptualization, Methodology, Investigation, Visualization, Writing - Original draft preparation, Reviewing and Editing; Yan Xia: Methodology, Validation, Investigation, Visualization, Writing - Reviewing and Editing; Qinhui Liu: Methodology, Resources, Investigation; Xiandan Jing: Methodology, Investigation; Qin Tang: Methodology, Funding acquisition; Jinhang Zhang: Methodology, Investigation; Qingyi Jia: Methodology, Investigation; Zijing Zhang: Methodology, Validation; Jiahui Li: Methodology, Validation; Jiahao Chen: Validation, Investigation; Yimin Xiong: Methodology, Validation; Yanping Li: Resources, Writing - Reviewing and Editing, Project administration, Funding acquisition; Jinhan He: Conceptualization, Resources, Supervision, Writing - Reviewing and Editing, Project administration, Funding acquisition."