Embedding routine health care data in clinical trials: with great power comes great responsibility.

"Conflict of interest M.L. Handoko received an educational grant from Novartis and Boehringer Ingelheim, and speaker/consultancy fees from Novartis, Boehringer Ingelheim, Daiichi Sankyo, Vifor Pharma, AstraZeneca, Bayer, MSD, Abbott and Quin, all not related to this work. F.S. de Man is currently Associate Editor of the Netherlands Heart Journal. J.J. Brugts received speaker/consultancy fees from Bayer, Novartis, Abbott and Vifor Pharma, all not related to this work. He is currently Associate Editor of the Netherlands Heart Journal. P. van der Meer received consultancy fees and/or grants from Novartis, Pharmacosmos, Vifor Pharma, AstraZeneca, Pfizer, Pharma Nord, BridgeBio, Novo Nordisk and Ionis, paid to the institute. H.F.M. Rhodius-Meester performs contract research for Combinostics; all funding is paid to her institution. J. Schaap received an educational grant and speaker/consultancy fees from Boehringer Ingelheim, Daiichi Sankyo, AstraZeneca, General Electric and Novo Nordisk, all not related to this work. H.J. R. van de Kamp, S. Houterman, D. van Veghel, A. Uijl and F.W. Asselbergs declare that they have no competing interests."

"Funding M.L. Handoko is supported by the Dutch Heart Foundation (2020T058) and Netherlands CardioVascular Research Initiative (CVON): the Dutch Heart Foundation, Dutch Federation of University Medical Centres, the Netherlands Organisation for Health Research and Development, and the Royal Netherlands Academy of Sciences (CVON; 2020B008). F.S. de Man is supported by CVON (2017-10, 2018-29) and is further supported by the Netherlands Organization for Scientific Research (918.16.610; 917.18.338) and the Dutch Heart Foundation Dekker (2018T059). P. van der Meer is supported by a grant from the European Research Council (ERC CoG 101045236, DISSECT-HF). H.F.M. Rhodius-Meester is a recipient of the Memorable Dementia Fellowship 2021 (ZonMw 10510022110004) and Alzheimer Nederland InterACT grant (WE.08-2022-06). F.W. Asselbergs is supported by Heart4Data, which received funding from the Dutch Heart Foundation and ZonMw (2021-B015), and UCL Hospitals NIHR Biomedical Research Centre."