The effector program of human CD8 T cells supports tissue remodeling.

"the accession numbers for human scrna-seq and sctcr-seq ( figs3 and s2 ) data reported in this paper are european genome-phenome archive egad00001010007 and egad00001010005 respectively.; the accession number for mrc-5 and hacat bulk rna-seq data ( fig 2 a and c ) reported in this paper is gene expression omnibus gse223989 . table s4 . all data"

"Disclosures: M. Delacher reported personal fees from Odyssey Therapeutics outside the submitted work. E.K. Geissler reported personal fees from Quell outside the submitted work. No other disclosures were reported."

"This work was supported by the European Research Council (ERC-CoG, #648145 REGiREG) to M. Feuerer. This work was funded by the Deutsche Forschungsgemeinschaft (German Research Foundation) Projektnummer 324392634—TRR221 TPB08 (to M. Feuerer) and SFB TRR305—TPB06 (to M. Feuerer), and Projektnummer 318346496—SFB1292/2 TP19N (to M. Delacher) and Projektnummer 490846870—TRR355/1 TPA01 (to J. Huehn and M. Delacher) and TPZ02 (to M. Delacher), and Else-Kröner-Fresenius-Stiftung 2020 EKEA.110 (to H. Junger). Author contributions: Conceptualization, M. Delacher and M. Feuerer; Methodology, M. Delacher, M. Simon, L. Schmidleithner, P. Stüve, and M. Feuerer; Software, M. Delacher, M. Simon, L. Schmidleithner, A. Hotz-Wagenblatt, N. Strieder, B. Brors, U. Ritter, and C.D. Imbusch; Investigation, Resources, M. Delacher, M. Simon, L. Schmidleithner, P. Stüve, L. Sanderink, M. Wuttke, K. Schambeck, B. Ruhland, V. Hofmann, S. Bittner, A. Pant, S.S. Helbich, M. Voss, N.A. Lemmermann, L. Bessiri-Schake, T. Bohn, A. Eigenberger, A.N. Menevse, C. Gebhard, H. Abken, M. Rehli, C. Schmidl, P. Beckhove, H. Junger, T. Hehlgans, L. Prantl, U. Ritter, and J.M. Werner; Writing—Original Draft, M. Delacher and M. Feuerer; Writing—Review & Editing, M. Delacher, M. Simon, L. Schmidleithner, P. Stüve, C. Schmidl, J. Huehn, and M. Feuerer; Visualization, M. Delacher, M. Simon, L. Schmidleithner, and C.D. Imbusch; Supervision: M. Delacher and M. Feuerer; Project Administration, M. Delacher and M. Feuerer; Funding Acquisition, M. Feuerer."