MANF protein expression is upregulated in immune cells in the ischemic human brain and systemic recombinant MANF delivery in rat ischemic stroke model demonstrates anti-inflammatory effects.

"Declarations Competing interestsThe authors declare there are no conflicts of interest. Competing interests The authors declare there are no conflicts of interest."

"Funding Open Access funding provided by University of Helsinki (including Helsinki University Central Hospital). This study was funded by Academy of Finland (grant numbers 250275, 256398, 281394); Biocentrum Helsinki; and Sigrid Jusélius Foundation. PJL was funded by Sigrid Jusélius Foundation; Jane and Aatos Erkko Foundation; and Helsinki University Hospital Research Funds. JEA and KM were supported by Ella and Georg Ehrnrooth Foundation. JEA was supported also by Päivikki and Sakari Sohlberg Foundation; Alfred Kordelin Foundation; Orion Research Foundation; Finnish Cultural Foundation. KYT was funded by the Ministry of Science and Technology of Taiwan R.O.C. (MOST 111-2314-B-016-051-MY3). Open access funded by Helsinki University Library."