Vitamin C facilitates direct cardiac reprogramming by inhibiting reactive oxygen species.

"availability of data and material our data have been deposited and can be fully accessed via: https://dataverse nl/dataset xhtml? availability of data and material our data have been deposited and can be fully accessed via: https://dataverse"

"Declarations Ethics approval and consent to participateHuman fetal heart tissue was obtained by individual permission using standard written informed consent procedures and has been approved by De medisch-ethische toetsingscommissie Leiden Den Haag Delft (METC LDD) with the number B21.053 entitled “Cardiopulmonary circulation” on December 16, 2021. This is in accordance with the principles outlined in the Declaration of Helsinki for the use of human tissue or subjects. All experiments were conducted according to the criteria of the code of proper use of human tissue used in the Netherlands. Consent for publicationNot applicable. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding This work is supported by the Project EVICARE (No. 725229) of the European Research Council (ERC) to J.P.G.S., the ZonMw-TAS program (No. 116002016) to J.P.G.S./Z.L., the Dutch Ministry of Economic Affairs, Agriculture and Innovation and the Netherlands CardioVascular Research Initiative (CVON): the Dutch Heart Foundation to J.P.G.S. Juntao Fang is supported by a Chinese Scholarship Council (CSC) fellowship program (No.201906210082). Renee G.C Maas is supported by the PLN Foundation and by the HARVEY project (18747 NWO OTP). The funding body played no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript."