Inherited polygenic effects on common hematological traits influence clonal selection on JAK2^V617F and the development of myeloproliferative neoplasms.

"data availability gwas summary statistics for the 29 blood cell traits were sourced from a published study (vuckovic et al 14 ) and are available from the gwas catalog ( https://www ebi ac uk/gwas/ ) with accession numbers gcst90002379 - gcst90002407 . data availability across traits) and ukbb controls ( n = ~140000"

"Competing interests The authors declare no competing interests."

"J.N. is a Cancer Research UK (CRUK) advanced clinician scientist fellow. Work in the Nangalia laboratory is supported by CRUK, Wellcome core funding, and the Alborada Trust and Rosetrees Trust. D.V. is a member of the health protection research unit in chemical and radiation threats and hazards, a partnership between Public Health England and Imperial College London, which is funded by the National Institute for Health Research (NIHR). J.D. holds a British Heart Foundation professorship and an NIHR senior investigator award. Samples from patients with MPN were provided by the Cambridge Blood and Stem Cell Biobank, which is supported by the Cambridge NIHR Biomedical Research Centre, the Wellcome Trust–MRC Stem Cell Institute and the Cambridge Experimental Cancer Medicine Centre, UK. We thank Q. Zhang, N. Williams and D. Leongamornlert at the Wellcome Sanger Institute (Cambridge, UK) and N. Pirastu at the Fondazione Human Technopole (Milan, Italy) for their thoughtful discussions and constructive advice."