Time-Controlled Adaptive Ventilation (TCAV): a personalized strategy for lung protection.

"Declarations Ethics approval and consent to participateNot applicable. Consent for publicationNot applicable. Competing interestsMKS has received a Research Grant and GFN an Unrestricted Educational Grant from Dräger Medical Systems, Inc. GFN, MKS have presented and received honoraria and/or travel reimbursement at event(s) sponsored by Dräger Medical Systems, Inc., outside of the published work. GFN, MKS, have lectured for Intensive Care On-line Network, Inc. (ICON). NMH is the founder of ICON, of which PLA is an employee. NMH holds patents on a method of initiating, managing and/or weaning airway pressure release ventilation, as well as controlling a ventilator in accordance with the same. DWK and JH are co-founders and shareholders of OscillaVent, Inc., and are co-inventors on a patent involving multi-frequency oscillatory ventilation. DWK and JH also receive research support from ZOLL Medical Corporation, and DWK is a consultant for Lungpacer Medical, Inc. JHTB is a consultant to and shareholder of OscillaVent, Inc., and has two patents pending in the field of MV. The authors maintain that industry had no role in the design and conduct of the study; the collection, management, analysis, or interpretation of the data; nor the preparation, review, or approval of the manuscript. Competing interests MKS has received a Research Grant and GFN an Unrestricted Educational Grant from Dräger Medical Systems, Inc. GFN, MKS have presented and received honoraria and/or travel reimbursement at event(s) sponsored by Dräger Medical Systems, Inc., outside of the published work. GFN, MKS, have lectured for Intensive Care On-line Network, Inc. (ICON). NMH is the founder of ICON, of which PLA is an employee. NMH holds patents on a method of initiating, managing and/or weaning airway pressure release ventilation, as well as controlling a ventilator in accordance with the same. DWK and JH are co-founders and shareholders of OscillaVent, Inc., and are co-inventors on a patent involving multi-frequency oscillatory ventilation. DWK and JH also receive research support from ZOLL Medical Corporation, and DWK is a consultant for Lungpacer Medical, Inc. JHTB is a consultant to and shareholder of OscillaVent, Inc., and has two patents pending in the field of MV. The authors maintain that industry had no role in the design and conduct of the study; the collection, management, analysis, or interpretation of the data; nor the preparation, review, or approval of the manuscript."

"Funding NIH R01HL142702—Support for Bates, Gaver, Nieman, Satalin, Blair. Office of the Assistant Secretary of Defense for Health Affairs, Peer Reviewed Medical Research Program, Award W81XWH-20-1-0696—Support for Nieman, Satalin, Blair, Kaczka, Habashi. Office of the Assistant Secretary of Defense for Health Affairs, Peer Reviewed Medical Research Program, Award W81XWH-20-1-0507—Support for Kaczka. Opinions, interpretations, conclusions and recommendations are those of the authors, and are not necessarily endorsed by the Department of Defense."