Whole genome sequencing unravels cryptic circulation of divergent dengue virus lineages in the rainforest region of Nigeria.

Journal Information

Full Title: Emerg Microbes Infect

Abbreviation: Emerg Microbes Infect

Country: Unknown

Publisher: Unknown

Language: N/A

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Subject Category: Communicable Diseases

Available in Europe PMC: Yes

Available in PMC: Yes

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"summary of denv reads detected in the three genomes included in the phylogenetic tree [ comment ] sequence id accession number biosample accession number of reads mapped reads mean coverage gc % coverage in relation to nc_001477 pairwise identity in relation to nc_001477 (%) dv36 or259173 samn35565128 24963042 11990 134 7 47 75 98 3 91 9 dv40 or259174 samn35565129 15155000 2557677 30217 7 47 31 99 7 92 0 dv44 or259175 samn35565130 25630416 30064 477 0 46 85 99 2 91 9 in our phylogeographic reconstructions the three nigerian sequences cluster as monophyly consistently (posterior 0 76 for the e gene 1 for whole genome nrr) suggesting the sampled lineage was established by a single introduction or represents a single undersampled endemic lineage ( figure 2 b).; data availability the sequenced raw reads for this study and the generated genomes have been deposited in ncbi under bioproject prjna979106 with accession numbers or259173-or259175 for the dengue genomes. data availability the sequenced raw reads for this study and the generated genomes have been deposited in ncbi under bioproject prjna979106"

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"Disclosure statement No potential conflict of interest was reported by the author(s)."

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"This work received support from ACEGID laboratory and TED’s Audacious Project, including the ELMA Foundation, MacKenzie Scott, and the Skoll Foundation. This work was supported by grants from the National Institute of Allergy and Infectious Diseases (https://www.niaid.nih.gov), award numbers U01HG007480 to C.T.H and U01AI151812 to E.P), NIH-H3Africa (https://h3africa.org) award number U54HG007480. The World Bank grants projects ACE-019 and ACE-IMPACT. This work was also supported by the Rockefeller Foundation (Grant #2021 HTH), the Africa CDC through the African Society of Laboratory Medicine [ASLM] (Grant #INV018978), and the Science for Africa Foundation. The authors thank Mr. Agbaje for facilitating the Ekiti University Teaching Hospital sample collection."

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Last Updated: Aug 05, 2025