hUC-MSCs-derived MFGE8 ameliorates locomotor dysfunction via inhibition of ITGB3/ NF-κB signaling in an NMO mouse model.

"data availability our expression date for huc-mscs during this study have been deposited in the geo database (gse246608).; public expression date for huc-mscs is available in the geo database (gse165811). data availability our expression date for huc-mscs during this study have been deposited in the geo database (gse246608"

"Competing interests The authors declare no competing interests."

"We thank Dr. Weixiang Guo and Dr. Qingfeng Wu for helpful discussion and Xiaoyan Han for technical assistance. This research was supported by grants from Science and Technology Plan Project of Guangzhou City grant 202201020489 (to C.T.) and 2023A04J1089 (to C.T.); the National Natural Science Foundation of China grant 32100787 (to C.T.) and 82071344 (to W.Q.); Guangzhou Municipal School (Hospital) Joint Funding (Dengfeng Hospital) Municipal Key Laboratory Construction Project 202102010009 (to W.Q.); Natural Science Foundation of Guangdong Province 2022A1515012398 (to W.Q.). Key-Area Research and Development Program of Guangdong Province 2023B1111050003 (to H.C.); Guangzhou Science and Technology Talent Project 201909020006 (to H.C.); Science and Technology Talent Project of Guangzhou Development District 2020-L035 (to H.C.); the National Key Research and Development Program “supplementary support” project of Guangzhou 2024B01J1137 (to X.L.)."