Circulating mitochondria promoted endothelial cGAS-derived neuroinflammation in subfornical organ to aggravate sympathetic overdrive in heart failure mice.

"Declarations Ethics approval and consent to participateThis study was carried out in accordance with the recommendations of the guidelines of the Animal Care Committee of the Fudan University, Shanghai, China. Animal Care and conformed to the guidelines by the Institutional Ethics Committee of the Zhongshan Hospital, Fudan University. The study was approved by the Experimental Animal Ethics Committee of Zhongshan Hospital, Fudan University, with ethics approval number B2022-315R. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding This work was supported by the Chinese National Natural Science Foundation 81900278 to Dajun Zhao, China Postdoctoral Science Foundation 2020M681178 to Dajun Zhao, and the Youth Fund of Zhongshan hospital, Fudan University 2020ZYYS-005 to Dajun Zhao. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."