MSCs mediate long-term efficacy in a Crohn's disease model by sustained anti-inflammatory macrophage programming via efferocytosis.

"data availability all raw sequencing data generated in this study have been deposited to the ncbi sequence read archive (sra) ( https://www ncbi nlm nih gov/sra ) under accession number prjna1052108. data availability all raw sequencing data generated in this study have been deposited to the ncbi sequence read archive (sra) ( https://www ncbi nlm nih gov/sra ) under accession number prjna1052108"

"code availability the codes for radiomic analysis are deposited on github at https://github com/ccipd/radiomic_mouse_analysis ."

"Competing interests The authors declare no competing interests."

"This work was supported by Crohn’s and Colitis Foundation Career Development Award 370615 (to M.D.), NIH grants: K08DK110421 (to M.D.), F.C. supported by P30DK097948, DK042191, DK091222 and, DK07948 grants, A.I.C. supported by P41 EB021911 grant, G.H.M. supported by Crohn’s and Colitis Foundation Senior Research Award 421904, HL126626 and HL141423 grants, V.C.O. supported by Swiss national science foundation grant: P2SKP3_178132. The authors thank Margie Harris for the assistance with hMSC isolation and culture, Mike Sorrell for isolation of human dermal fibroblast. We duly acknowledge The DNA Technologies and Expression Analysis Core, Bioinformatics Core, Genome Center UC Davis, Dr. Lutz Froenicke, Dr. Hong Qiu, and Dr. Jie Li, for single-cell RNA sequencing. We also thank Dr. Chris A. Flask, Case Center for Imaging Research, Case Western Reserve University and Center for Molecular and Genomic Imaging, UC Davis for providing small animal in vivo imaging facilities."