Multi-omics and pathway analyses of genome-wide associations implicate regulation and immunity in verbal declarative memory performance.

"three curated human (gds4135 [ ] gds4231 [ ] gds4358 [ ]) and rodent (gds2082 [ ] gds2639 [ ] gds520 [ ]) gene expression studies of cognitive traits were selected from the gene expression omnibus [ ]; descriptions of each study are provided in the supplemental text ."

"Declarations Ethics approval and consent to participateThis study utilized summary results specific to each cohort from a previously published genome-wide association study (GWAS) on verbal declarative memory. Each cohort received approval from the relevant institutional review boards. All participants provided written informed consent for study participation, cognitive testing, and use of their genetic information for research. In this study, we rely on publicly accessible, extensive datasets rather than individual-level data. As a result, ethical approval was not pursued. Consent for publicationNot applicable. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests. "

"Funding This work was accomplished as a part of the CHARGE project (CHARGE consortium: omics discovery for CVD and aging phenotypes. NIH R01HL105756), and was funded by grant U01-HL096917 from the National Institutes of Health (NIH) / NIH Heart, Lung and Blood Institute, http://www.nhlbi.nih.gov/. Hao Mei and Jeannette Simino are also partially funded by National Institute of General Medical Sciences grant 1P20GM144041 which established the Molecular Center of Health and Disease at the University of Mississippi Medical Center. Lianna Li is funded by National Science Foundation grant 2100805. Stéphanie Debette is a recipient of a Chaire d’Excellence Grant from the French national research agency (Agence Nationale de la Recherche). Hans Grabe has received travel grants and speaker’s honoraria from Fresenius Medical Care, Neuraxpharm, Servier, and Janssen Cilag as well as research funding from Fresenius Medical Care."