ZMIZ2 facilitates hepatocellular carcinoma progression via LEF1 mediated activation of Wnt/β-catenin pathway.

"gene expression of zmiz2 of hcc and normal tissues were obtained from publicly available datasets including the cancer genome atlas (tcga)-lihc cohort and gene expression omnibus (geo) datasets (accession number: gse54236 gse55092 and gse144269)."

"Declarations Ethics approval and consent to participateThis study was approved by the ethics committee of Zhongnan Hospital of Wuhan University (Approval No.2022011 K), and all individuals provided informed consent for inclusion of their tissues in this study. Moreover, all animal experimental procedures were approved by the Experimental Animal Welfare Ethics Committee, Zhongnan Hospital of Wuhan University (Approval No. ZN2022088). Consent for publicationNot applicable. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding This study was sponsored by grants from the National Nature Science Foundation of China (No.82172983, 81670554, 82073095), the Wuhan Science and Technology Project (No.2020020601012208), science and technology innovation and cultivation fund of Zhongnan Hospital of Wuhan University (No. CXPY2020042) and subjects and platform construction in Zhongnan Hospital of Wuhan University (No. PTXM2020003)."