Sputum Transcriptomics Reveals FCN1+ Macrophage Activation in Mild Eosinophilic Asthma Compared to Non-Asthmatic Eosinophilic Bronchitis.

"all sequencing data have been deposited in public open access repository of nih's sequence read archive (sra) (bioproject: prjna878650). details of methods are provided in the supplementary data s1 .; supplementary materials supplementary data s1 method supplementary table s1 differentially expressed genes of eosinophilic asthma compared with healthy subjects supplementary table s2 differentially expressed genes of eosinophilic bronchitis compared with healthy subjects supplementary table s3 gene ontology term enrichment of biological processes for common 1011 upregulated genes supplementary table s4 differentially expressed genes of eosinophilic asthma compared with eosinophilic bronchitis supplementary table s5 clinical features of participants who completed single cell rna sequencing supplementary table s6 gene expression across different celltypes of sputum cell supplementary table s7 up-regulated genes of fcn1+ macrophage in eosinophilic asthma compared to eosinophilic bronchitis supplementary table s8 gene set enrichment analysis of fcn1+ macrophage of eosinophilic asthma compared to eosinophilic bronchitis supplementary references"

"Disclosure: There are no financial or other issues that might lead to conflict of interest."

"This study was supported by Key-Area Research and Development Program of Guangdong Province (2019B020227006); Guangdong Natural Science Foundation Major Basic Cultivation Project (2018B030308004); Guangzhou Municipal Science and Technology Key Project (2002Z2-E0091); Incubative Project for Innovation Team of Guangzhou Medical University (2017-159); Clinical Research Foundation of Guangzhou Medical University (2017-160); Open Fund Programs of Shenzhen Bar Laboratory (SZBL2020090501003), and National Nature Science Foundation of China [32071452]. The founders had no role in study design, data collection and analysis, the decision to publish, or manuscript preparation."