Clinically relevant molecular hallmarks of PFA ependymomas display intratumoral heterogeneity and correlate with tumor morphology.

"concerning the pairs of primary and first relapse tumors evaluated we included patients of the university hospital hamburg-eppendorf cases from the capper et al cohort [ ] and two primary relapse pairs (r13 and r14) originally published by wenger et al in 2022 (geo accession gse247880) [ ].; data availability statement all newly generated dna methylation and spatial transcriptomic data presented in this manuscript are available on geo under the superseries accession gse248811. data availability statement all newly generated dna methylation and spatial transcriptomic data presented in this manuscript are available on geo under the superseries accession gse248811"

"Funding Open Access funding enabled and organized by Projekt DEAL. The funding has been received from Deutsche Forschungsgemeinschaft and the Fördergemeinschaft Kinderkrebs-Zentrum Hamburg."