Disturbed atrial metabolism, shear stress, and cardiac load contribute to atrial fibrillation after ablation: AXAFA biomolecule study.

"Conflict of interest: K.G.H. reports lecture fees/advisory board fees from Abbott, Alexion, Amarin, AstraZeneca, Bayer, Biotronik, Boehringer Ingelheim, Bristol Myers Squibb, Daiichi Sankyo, Edwards Lifesciences, Medtronic, Pfizer, Premier Research, SUN Pharma, and W. L. Gore & Associates. R.B.S. has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme under the grant agreement no. 648131, from the European Union’s Horizon 2020 research and innovation programme under the grant agreement no. 847770 (AFFECT-EU), German Center for Cardiovascular Research (DZHK e.V.; 81Z1710103), German Ministry of Research and Education (BMBF 01ZX1408A), and ERACoSysMed3 (031L0239). R.B.S. has received lecture fees and advisory board fees from BMS/Pfizer outside this work. P.K. receives research support for basic, translational, and clinical research projects from the European Union, British Heart Foundation, Leducq Foundation, Medical Research Council (UK), and German Centre for Cardiovascular Research, from several drug and device companies active in atrial fibrillation, and has received honoraria from several such companies in the past, but not in the last 3 years. P.K. is listed as inventor on two patents held by University of Birmingham (Atrial Fibrillation Therapy WO 2015140571, Markers for Atrial Fibrillation WO 2016012783). U.S. received research grants from the Netherlands Heart Foundation (CVON2014-09, RACE V Reappraisal of Atrial Fibrillation: Interaction between hyperCoagulability, Electrical remodeling, and Vascular Destabilisation in the Progression of AF) and the European Union (ITN Network Personalize AF: Personalized Therapies for Atrial Fibrillation: a translational network, grant number 860974; CATCH ME: Characterizing Atrial fibrillation by Translating its Causes into Health Modifiers in the Elderly, grant number 633196; MAESTRIA: Machine Learning Artificial Intelligence Early Detection Stroke Atrial Fibrillation, grant number 965286; REPAIR: Restoring cardiac mechanical function by polymeric artificial muscular tissue, grant number 952166). U.S. received consultancy fees or honoraria from Università della Svizzera Italiana (USI, Switzerland), Roche Diagnostics (Switzerland), EP Solutions Inc. (Switzerland), Johnson & Johnson Medical Limited (UK), and YourRhythmics BV. U.S. is co-founder and shareholder of YourRhythmics BV, a spin-off company of the University Maastricht. U.-H.W.-T. is an employee of Roche Diagnostics. T.Z. received funding from the German Science Foundation, German Center for Cardiovascular Research (DZHK e.V.; 81Z1710101, partner site project), The European Union euCanSHare project (grand agreement 825903), the ERA CVD project PREMED-CAD (FKZ01KL1807), and the ERA PerMed project (01KU1910B) outside this work. L.M. reports honoraries as consultant, lecturer, and advisory board from Boston Scientific, Abbott Medical, Johnson & Johnson, and Medtronic. He is a shareholder of Galgo Medical SL. J.P. is supported by R01AG074185 from the National Institutes of Aging, grants for clinical research from Abbott, American Heart Association, the Association for the Advancement of Medical Instrumentation, Bayer, Boston Scientific, iRhythm, and Philips, and serves as a consultant to Abbott, AbbVie, Bayer, Biotronik, Boston Scientific, Bristol Myers Squibb, Element Science, Itamar Medical, LivaNova, Medtronic, Milestone, ElectroPhysiology Frontiers, ReCor, Sanofi, Philips, and Up-to-Date. The other authors have nothing to disclose. L.F. received institutional research support from EU Horizon 2020 CATCH ME (grant agreement number 633196), and MAESTRIA (grant agreement number 965286). L.F. has received funding from Accelerator Award by the British Heart Foundation AA/18/2/34218. L.F. is further part-funded by National Institute for Health and Care Research (NIHR) award 1002898 (APRAISE-AS) at University of Birmingham, AFFECT-EU grant agreement number 847770 and German Center for Cardiovascular Research (DZHK)."

"Funding AXAFA–AFNET5 received support from BMS/Pfizer and the German Centre for Cardiovascular Research supported by the German Ministry of Education and Research (DZHK). The analyses reported here were supported in part by European Union-funded CATCH ME (grant agreement no. 633196) and MAESTRIA (grant agreement 965286), both to P.K., U.S., and L.F. Biomolecule quantification was performed by Roche Diagnostics as an in-kind donation to the CATCH ME project. J.C.N. was supported by a grant from the Novo Nordisk Foundation (NNF16OC0018658) outside this work. U.-H.W.-T. is an employee of Roche Diagnostics."