A novel AML1-ETO/FTO positive feedback loop promotes leukemogenesis and Ara-C resistance via stabilizing IGFBP2 in t(8;21) acute myeloid leukemia.

"the mass spectrometry proteomics data have been deposited to the proteomexchange consortium via the iprox partner repository [ ] with the dataset identifier pdx048441."

"Declarations Ethics approval and consent to participateThis research was conducted in accordance with international guidelines and the ethical standards outlined in the Declaration of Helsinki. This study was approved by the Medical Ethics Committee of Shenzhen University General Hospital and written informed consent was obtained from each patient for the use of their bone marrow samples. All animal experiments were conducted in compliance with the institutional guidelines for the Care and Use of Laboratory Animal by International Committees. All animal procedures were approved by the Experimental Animal Ethics Committee of Shenzhen University General Hospital. Consent for publicationNot applicable. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding This work was supported by grants from National Natural Science Foundation of China (82070161 to YL, 81870134 to YL, 82030076 to LY, 81970151 to LY, and 82100164 to WG), China Postdoctoral Science Foundation (2021TQ0217 to WZ), Science, Technology and Innovation Commission of Shenzhen Municipality (JCYJ20220531103003007 to YL), Natural Science Foundation of Guangdong Province (2022A1515012465 to YL), Medicine Plus Project of Shenzhen University (2023YG005 to YL), Natural Science Foundation of Shenzhen University General Hospital (SUGH2020QD008 to YL), Shenzhen Key Laboratory Foundation (ZDSYS20200811143757022 to LY), Sanming Project of Shenzhen (SZSM202111004 to LY), Italian Ministry of University and Research (PRIN-2017WWB99Z to CN) and Sapienza University of Rome (RM12117A8691212C to CN)."