Intelligent nanoreactor coupling tumor microenvironment manipulation and H₂O₂-dependent photothermal-chemodynamic therapy for accurate treatment of primary and metastatic tumors.

"Declaration of competing interest The authors declare that they have no competing interests."

"This work was supported by the National High Level Talents Special Support Plan (X.C.), the 10.13039/501100001809National Natural Science Foundation of China (82272141 to X.C.), the “Young Talent Support Plan” of Xi'an Jiaotong University (X.C.), the Shaanxi Innovative Research Team of Science and Technology (S2023-ZC-TD-0152), the 10.13039/501100007128Natural Science Foundation of Shaanxi Province (2022JZ-48 to X.C.), the National Key Research and Development Program of China (2023YFC2509104 to X.C.), and the Postdoctoral Science Foundation of China (2023M732812 to T.L.). Jie Liu: Data curation, Investigation, Writing – original draft. Tianfeng Yang: Data curation, Investigation. Handan Zhang: Formal analysis. Lin Weng: Formal analysis. Xiuhong Peng: Investigation. Tao Liu: Investigation, Writing – review & editing. Cheng Cheng: Formal analysis, Investigation. Yanmin Zhang: Supervision, Writing – review & editing. Xin Chen: Conceptualization, Funding acquisition, Supervision, Writing – review & editing."