BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia.

"single-cell rna sequencing data generated from this study are available through the ncbi gene expression omnibus (geo) under accession number gse253394.; single-cell rna sequencing data generated from this study are available through the ncbi gene expression omnibus (geo) under accession number gse253394 cd4 t helper cells play a central role in adaptive immunity by providing essential help to both antibody-producing b cells and cytotoxic cd8 t cells in addition to eliciting their own effector functions.; data generated from this study are available through the ncbi gene expression omnibus (geo) under accession number gse253394."

"The authors have declared that no competing interests exist."

"This study was supported by grants from the National Institutes of Health to LXL (R01 AI139124 and P20 GM103625) and LH (R21 AI175738), and Careers in Immunology Fellowship from the American Association of Immunologists to MABM. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."