Tumor-derived KLK8 predicts inferior survival and promotes an immune-suppressive tumor microenvironment in lung squamous cell carcinoma.

"the infiltration score of various immune cells and stroma cells within the tumor microenvironment for low-klk8 and high-klk8 patient groups were calculated by xcell cibersort epic and mcp-counter algorithm based on the transcriptome data of the tcga lusc dataset (supplementary data 1 ).; the klk8 score and clinical information of each sample in our cohort were recorded in supplementary data 2 .; additional file 1: supplementary data 1.; additional file 2: supplementary data 2."

"Declarations Ethics approval and consent to participateThe studies involving human participants were reviewed and approved by the National Cancer Center/Cancer Hospital Ethics Committee, the Chinese Academy of Medical Sciences, and Peking Union Medical College. The patients/participants provided their written informed consent to participate in this study. Written informed consent was obtained from the individuals to publish any potentially identifiable images or data included in this article. We confirm that all methods were carried out in accordance with relevant guidelines and regulations. Consent for publicationNA. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding This work was supported by the Special Research Fund for Central Universities, Peking Union Medical College (3332022132, 3332021028, 3332021029); the Beijing New-star Plan of Science and Technology (Z211100002121055); the CAMS InnovationFund for Medical Sciences (CIFMS) 2021–1-I2M-012, National Natural Science Foundation of China (No: 81972196, 8210103136, 82060426, 81702274); the National Key R&D Program of China (2020AAA0109505); the Beijing Municipal Science & Technology Commission (Z191100006619119); Beijing Hope Run Special Fund of Cancer Foundation of China [LC2018B14, LC2020B09]."