FBXO38 deficiency promotes lysosome-dependent STING degradation and inhibits cGAS-STING pathway activation.

"all sequencing data have been uploaded to the gene expression omnibus database under the accession number gse220879 and gse246258."

"Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper."

"Funding This work was supported by the General Program of the 10.13039/501100001809National Natural Science Foundation of China (No. 81972667 to J.S.), the 10.13039/501100013290National Key R&D Program of China (2021YFC2701103 to J.S.), the Shanghai Key Clinical Specialty, Shanghai Eye Disease Research Center (2022ZZ01003), and the Shanghai Municipal Education Commission-Two Hundred Talent (No. 20191817 to J.S.)."