Coenzyme Q10 mitigates macrophage mediated inflammation in heart following myocardial infarction via the NLRP3/IL1β pathway.

"the rna-seq datasets generated and analyzed during the current study are available in the [bioproject database] repository [ http://www ncbi nlm nih gov/bioproject/979940 ; bioproject id: prjna979940]."

"Declarations Ethics approval and consent to participateThe study protocol was approved by the Ethics Committee of Xinqiao Hospital, Army Medical University (2021-041-01), all eligible patients supplied written informed consent, and the study was performed in accordance with the Declaration of Helsinki. The Laboratory Animal Welfare and Ethics Committee of the Army Medical University approved all the animal procedures. All methods are reported in accordance with ARRIVE guidelines (https://arriveguidelines.org) for the reporting of animal experiments. Consent for publicationNot applicable. Competing interestsThe authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Competing interests The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest."

"Funding This work was supported by the National Natural Science Foundation of China 82100218 (Y.W.), Chongqing Doctoral Research Fund CSTB2022BSXM-JCX0023 (Y.W.), Chongqing Innovation Support Program for Returned Overseas Scholars cx2020010 (Y.W.), Young Doctoral Talent Program 2022YQB009 (Y.W.), and Chongqing Talent Program CQYC201903087 (J.J.)."

"Trial registration Date of registration 09/04/2021 (number: ChiCTR2100045256)."