Drug-Coated Balloon for de-novo Coronary Artery Lesions Exceeding 2.5 mm in Diameter: Optical Coherence Tomography Analysis and Clinical Follow-Up.

"Disclosure The authors report no conflicts of interest in this work."

"This study was supported by the National Natural Science Foundation of China (82170252)."

"This was an observational and prospective study. The registry included all consecutive patients referred to the First Affiliated Hospital of Dalian Medical University for PCI of de-novo lesions between January 2021 and April 2022. Data on patient baseline characteristics, procedural details, and in-hospital outcomes were collected from medical records and a database. Patients aged > 18 years and symptomatic CAD and de-novo lesions in native coronary arteries (vessel diameter > 2.5 mm) were included. Patients with acute MI within 48 h, ISR lesions, lesions in the left main coronary artery, severely calcified lesions, or vessel size ≤ 2.5 mm were excluded. Therefore, 53 patients with 55 de-novo coronary lesions in vessels > 2.5 mm in diameter were included in the present study. This study has been registered on the ClinicalTrials.gov (NCT04984135). Clinical follow-up of the registry after index CAG was performed at 1, 3, 6 and 9 months."