A theragenerative bio-nanocomposite consisting of black phosphorus quantum dots for bone cancer therapy and regeneration.

"Declaration of competing interest The authors have declared that there is no conflict of interest."

"The authors acknowledge support from Progetto MIUR PRIN2017–ACTION, Grant No. 2017SZ5WZB and POR Campania FESR 2014–2020 (Campania imaging Infrastructure for Research in Oncology – C.I.R.O). The authors also thank Maria Rosaria Bonetti for lab technical support, Cristina Del Barone for facilitating microscopy analysis, Dr. Antonio Pennetta for ICP analysis and Dr. Roberta Marzella for support to project management. CISUP (Centre for Instrument Sharing-University of Pisa) and the EUroBioImaging (EUBI) Facility at CNR (Naples) are acknowledged for the use of the Bruker Avance NEO 500 Solid State NMR spectrometer and of AxioVision microscope (Carl Zeiss Micro Imaging GmbH), respectively. Ashkan Bigham: Writing – original draft, Validation, Software, Methodology, Investigation, Data curation, Conceptualization. Ines Fasolino: Methodology, Investigation. Silvia Borsacchi: Writing – review & editing, Methodology, Investigation, Formal analysis. Carmen Valente: Writing – review & editing, Methodology, Investigation. Lucia Calucci: Methodology. Gabriele Turacchio: Methodology, Investigation. Marianna Pannico: Methodology, Investigation. Manuel Serrano-Ruiz: Methodology, Investigation, Formal analysis. Luigi Ambrosio: Writing – review & editing, Supervision, Resources. Maria Grazia Raucci: Writing – review & editing, Supervision, Resources, Project administration, Funding acquisition, Data curation, Conceptualization."