Longitudinal dynamics of gut bacteriome and mycobiome interactions pre- and post-visceral surgery in Crohn's disease.

"Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest."

"The author(s) declare financial support was received for the research, authorship, and/or publication of this article. MB is supported by the IMM-PACT-Program for Clinician Scientists of the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [413517907]. The Ministry of Science, Research and Arts of the state of Baden-Württemberg, Germany, financed the position of AKL within the Academic Center for Complementary and Integrative Medicine (AZKIM); otherwise, the study was financed by institutional resources."

"This subgroup analysis investigates results from all patients suffering from CD, of a prospective cohort trial, which was performed at the Department for General and Visceral Surgery, University Medical Center Freiburg from April 2018 to August 2020. We evaluated the postoperative alteration of the gut microbiome in CD patients undergoing colorectal surgery. Inclusion criteria were age above 18 years, elective left or right hemicolectomy, sigmoid resection, deep anterior rectal resection, ileocecal resection or restoration of continuity without ostomy creation. Emergency surgeries were not considered. Before inclusion in the study, written consent was obtained from all patients after a detailed consultation. The study was approved by the local ethical committee, Medical Center—University of Freiburg, (EK-FR: 535/17) and was registered at the German Clinical Trial register (DRKS00014059)."