Estradiol enhanced neuronal plasticity and ameliorated astrogliosis in human iPSC-derived neural models.

"Declaration of competing interest Hideyuki Okano is a founder scientist and a Scientific Advisory Board Member for SanBio Co., Ltd., and K Pharma Inc. The remaining authors declare no conflicts of interest."

"Funding This research was funded by the Grants-in-Aid for Scientific Research (KAKENHI, #21J21244 to SS, #21H02450, #23K18116, and #21K06376 to SM), the Keio Global Research Institute from Keio University (to SM and HO), the Japan Agency for Medical Research and Development (AMED) [The Acceleration Program for Intractable Disease Research Utilizing Disease-specific iPS Cells to SM and HO (JP21bm0804003)], [Research and Development Grants for Dementia to SM (22dk0207060)], the Keio University Doctorate Student Grant-in-Aid Program from Ushioda Memorial Fund 2021 (to SS), and the research grant from Keio Medical Association (the fiscal year 2022) (to SS)."