Clinical practice and effect of carbon dioxide on outcomes in mechanically ventilated acute brain-injured patients: a secondary analysis of the ENIO study.

"Declarations Conflicts of interestThe authors declare that the article content was composed in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Ethics approval and consent to participateApproval to conduct this sub-analysis was not necessary. Approval to enroll patients in the ENIO main study was obtained from the International Review Board (IRB) of the promoter center (Groupe Nantais d’Éthique dans le Domaine de la Santé, IRB No. 7/11/2017), and from the local IRB for each participating center. Consent for publicationInformed consent was generally waived in accordance with the observational nature of the ENIO study, but if necessary was collected in accordance with the local regulations of each IRB involved. Informed consent was obtained from the patient or from the patient’s neck of kin if the patient was unable to give the consent at the time of enrollment. Conflicts of interest The authors declare that the article content was composed in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest."

"Funding Open access funding provided by Università degli Studi di Genova within the CRUI-CARE Agreement. The work was supported by #NEXTGENERATIONEU (NGEU) and funded by the Ministry of University and Research (MUR), National Recovery and Resilience Plan (NRRP), under Project No. MNESYS (PE0000006)—a multiscale integrated approach to the study of the nervous system in health and disease (DN. 1553 11.10.2022)."

"This is a preplanned secondary analysis of a worldwide, multicenter, observational cohort study named “Extubation strategies in Neuro-Intensive care unit patients and associations with Outcomes” (ENIO) (registration number NCT03400904) conducted between June 2018 and November 2020 []. ENIO was endorsed by the PROtective VEntilation Network (PROVE Net), the ESICM, the French Society of Anesthesiology and Critical care (SFAR), and Colegio Mexicano de Medicina Critica (CMMC). The study protocol was approved by the International Review Board (IRB) of the Groupe Nantais d’Éthique dans le Domaine de la Santé, Nantes, France (IRB No. 7/11/2017), and then by each participating site. Informed consent was collected in accordance with the local regulations. Initial approval also included the secondary analysis, which underwent a preliminary evaluation and was approved by the Steering Committee of ENIO. This study was conducted according to the STROBE reporting guidelines for observational studies [] (electronic supplementary material, ESM, Table )."