Differences in bacterial taxa between treatment-naive patients with major depressive disorder and non-affected controls may be related to a proinflammatory profile.

"data availability the datasets used and/or analyzed during the current study are available in the ncbi sequence at https://www ncbi nlm nih gov/bioproject/prjna1054468 . data availability the datasets used and/or analyzed during the current study are available in the ncbi sequence at https://www ncbi nlm nih gov/bioproject/prjna1054468"

"Declarations Ethics approval and consent to participateThe study was conducted in accordance with the Declaration of Helsinki and approved by the North Denmark Regional Ethical Committee (reference: N-20170056). The categories of the personal data collected in the project are registered in the processing activities of research in the North Region of Denmark in compliance with EU GDPR article 30. Written and oral informed consent was obtained from all participants. No personal data from any participants were included in the study, and participants were informed of this prior to signing their informed consent sheet. Competing interestsThe authors declare no competing interests. Consent for publicationNot applicable. Competing interests The authors declare no competing interests."

"Funding Funding for this study was obtained from the following: Peder Kristen Tøfting and Dagmar Tøftings Fond, Savværksejer Jeppe Juhl and hustru Ovita Juhls Mindelegat, Svend Andersen Fonden, L. F. Foghts Fond, Else og Mogens Wedell-Wedellsborgs Fond, and Marie Pedersen and Jensine Heibergs Legat. None of the funders had any role in the conceptualization, design, data collection, analysis, decision to publish, or preparation of the manuscript."