Heterogeneous DNA hydrogel loaded with Apt02 modified tetrahedral framework nucleic acid accelerated critical-size bone defect repair.

"Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper."

"This work was financially supported by 10.13039/501100001809National Natural Science Foundation of China (82230071, 82172098), Integrated Project of Major Research Plan of 10.13039/501100001809National Natural Science Foundation of China (92249303), Shanghai Committee of Science and Technology (23141900600, Laboratory Animal Research Project), Shanghai Clinical Research Plan of SHDC2023CRT01. Yafei Han: Writing – original draft, Methodology, Investigation, Formal analysis, Data curation, Conceptualization. Yan Wu: Methodology, Funding acquisition, Data curation. Fuxiao Wang: Methodology, Investigation, Formal analysis, Data curation. Guangfeng Li: Project administration, Methodology, Data curation. Jian Wang: Supervision, Software. Xiang Wu: Visualization, Validation. Anfu Deng: Software. Xiaoxiang Ren: Methodology, Conceptualization. Xiuhui Wang: Supervision, Formal analysis. Jie Gao: Validation, Supervision, Conceptualization. Zhongmin Shi: Visualization, Validation. Long Bai: Writing – review & editing, Visualization, Conceptualization. Jiacan Su: Writing – review & editing, Supervision, Resources, Funding acquisition, Conceptualization."