Neutralizing monoclonal antibodies against the Gc fusion loop region of Crimean-Congo hemorrhagic fever virus.

"the cryo-em maps and atomic models were deposited into the electron microscopy data bank and pdb with accession codes emd-36368 and 8jkd (sgc-trimer) emd-36406 and 8jlw (local reconstruction of gc8 in complex with the sgc-trimer) and emd-36407 and 8jlx (local reconstruction of gc13 in complex with the sgc-trimer) s1 fig (pdf) click here for additional data file s2 fig representative negative staining micrographs of cchfv gc (a) the gc-gc8 complex (b) and the gc-gc13 complex (c). data availability the cryo-em data is available at the following links: pdb doi"

"M.W., L.L., Z.H., S.C., L.P., and Y.S. filed a patent for Gc13 in treatment of CCHF to China Intellectual Property Office. Remaining authors declare no conflicts of interests."

"This work was supported by grants from the National Key R&D Program of China (2022YFC2303300 to Z.H.; 2023YFC2305900 to M.W.; 2021YFF0702002 to J.L.), the National Natural Science Foundation of China (U22A20336 to Z.H.), Hubei Natural Science Foundation for Distinguished Young Scholars (2021CFA050 to M.W.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB0490000 to Z.H.). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."