Prognostic and predictive value of angiogenesis-associated serum proteins for immunotherapy in esophageal cancer.

"the final assay readout is presented in normalized protein expression values which is an arbitrary unit on a log2-scale where a higher value corresponds to a higher protein expression 10 1136/jitc-2022-006616 supp1 supplementary data 10 1136/jitc-2022-006616 supp2 supplementary data measurements were performed using 1 ul of each sample.; specially we found that cd5 and il-15 were elevated after treatment only in responders while 30 plasma proteins were detected to be altered in nrs ( online supplemental figure s2 ) 10 1136/jitc-2022-006616 supp4 supplementary data 10 1136/jitc-2022-006616 supp5 supplementary data to explore the utility of plasma for ici prediction we analyzed the association between pretreatment plasma protein levels and survival outcomes.; our results support the application of plasma proteome sequencing and provide a clinical implication for combinations of icis with antiangiogenic therapy in the future 10 1136/jitc-2022-006616 supp3 supplementary data 10 1136/jitc-2022-006616 supp7 supplementary data we thank the patients and their families for their contribution to this study."

"Competing interests: None declared."

"Funding: This work was supported by the National Key Research and Development Program of China (2020YFE0202200), the State Key Program of National Natural Science Foundation of China (grant 92159106), the National Youth Top-Level Talent Support Program of Chain (12Y4962)."