Neuroinflammatory disease signatures in SPG11-related hereditary spastic paraplegia patients.

"Declarations Conflict of interestThe authors report no competing interests. Conflict of interest The authors report no competing interests."

"Funding Open Access funding enabled and organized by Projekt DEAL. This project was funded by the German Federal Ministry of Education and Research (BMBF TreatHSP consortium 01GM1905B, 01GM2209B, 01GM2209C and ACS iIMMUNE 01EO2105) and the “Förderverein für HSP-Forschung”. L.K., P.S., V.R., J.W., B.W. and M.R. are members of the DFG research training group RTG2162 ‘Neurodevelopment and Vulnerability of the Central Nervous System’ of the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation—270949263/GRK2162) and the CRU5024 (505539112). Further support came from the Bavarian Ministry of Science and the Arts in the framework of the ForInter network (M.J.R., B.W. and J.W.), the Research Foundation Medicine at the University Hospital Erlangen, Germany, the Tom Wahlig Foundation, the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation - FOG2625 HU800/13–2 to C.H., GU1431/5-1 to C.G., 401772351 to V.R., RO4866-1/1, 2/1, 3/1, 4/1, 5/1, 6/1 to V.R., 408885537-TRR274 to V.R., 261193037-CRC 1181 to V.R., 405969122-FOR2886 to V.R.), and the IZKF University Hospital Erlangen (J94 and CSP to P.S., N5 to C.G., ELAN-P119 to I.S.). TT was funded by the Kommission für Klinische Forschung (KKF), Klinikum rechts der Isar, Technical University Munich. J.Ba. was supported by the EU Horizon 2020 program (Solve-RD under grant agreement No 779257) and by a Senior Clinical Researcher mandate of the Research Fund—Flanders (FWO) under grant agreement number 1805021N. J.Ba. is a member of the European Reference Network for Rare Neuromuscular Diseases (ERN EURO–NMD), of the European Reference Network for Rare Neurological Diseases (ERN–RND), and of the µNEURO Research Centre of Excellence of the University of Antwerp."