Wnt/β-catenin signalling activates IMPDH2-mediated purine metabolism to facilitate oxaliplatin resistance by inhibiting caspase-dependent apoptosis in colorectal cancer.

"Declarations Ethics approval and consent to participateAll animal experiments were approved by the Animal Ethics Committee of The Sixth Affiliated Hospital, Sun Yat-sen University (IACUC-2023051101). Consent for publicationNot applicable. Competing interestsAll authors declare no competing interests and approve the manuscript for publication. Competing interests All authors declare no competing interests and approve the manuscript for publication."

"Funding This work was supported by a grant from the National Natural Science Foundation of China (No. 81301978, 81970191 and No. 32170789), Guangzhou Science and Technology Program (202002030348), Guangdong Nature Science Foundation of China (2022A1515012252), Guangdong Provincial Clinical Research Center for Digestive Diseases (2020B1111170004), and Fund of Shenzhen Key Laboratory (ZDSYS20220606100803007)."