Long-term outcomes of left atrial appendage closure with or without concomitant pulmonary vein isolation:a propensity score matching analysis based on CLACBAC study.

"Declarations Ethics approval and consent to participateThis study was approved by the Medical Research Ethics Committee of Shanghai Tenth People’s Hospital. All methods were conducted in accordance with pertinent guidelines and regulations. All primary investigations included in this study obtained ethical approval from the relevant review board, and all participants provided informed consent. Consent for publicationNot applicable. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding Funding for this study is provided by the Science and Technology Commission of Shanghai Municipality (Recipient: Xiaobing Yin, Grant No. 22692107900); Shanghai Hospital Development Centre (Recipient: Xiaobing Yin, Grant No. SHDC22022223); National Natural Science Foundation of China (Recipient: Yang Su, Grant No.82300431); Shanghai Tenth People’s Hospital (Recipient: Yang Su, Grant No. YNCR2C006, 2023YJXYSB012); Shanghai Tenth People’s Hospital (Recipient: Yan Jiang, Grant No. SYZKHLRC-C13); and Shanghai Tenth People’s Hospital Chongming Branch (Recipient: Hui Sun, Grant No. CKY2022–25)."

"This retrospective cohort study utilized data from the registered “Combining Left Atrial Appendage Closure with Cryoballoon Ablation in the Chinese Population” trial (CLACBAC, registration number NCT04185142). The study encompassed 333 consecutive non-valvular atrial fibrillation (AF) patients who underwent either left atrial appendage closure alone (n = 134) or a combination of left atrial appendage closure and pulmonary vein isolation (LAAC + PVI) (n = 199) at Shanghai Tenth People’s Hospital between May 2017 and November 2019. Inclusion criteria comprised [] patients diagnosed with AF, whether persistent or paroxysmal []; patients who underwent percutaneous LAAC alone or LAAC + PVI procedures []; CHA2DS2-VASc score ≥ 2 or HAS-BLED score ≥ 3. Exclusion criteria included [] valvular heart disease []; patients with arrhythmias other than AF []; patients who underwent interventions in the intracardiac cavity other than LAAC and PVI []; patients in whom occluder implantation failed for any reason. Additionally, a cohort of patients who underwent PVI alone was included for comparing AF recurrence rates between the PVI alone group and the combined group. Propensity score matching between these two groups was performed to balance baseline differences. The study received approval from the Medical Research Ethics Committee of Shanghai Tenth People’s Hospital, and all procedures were conducted following thorough pre-procedural evaluation upon hospital admission."