Nano oxygen chamber by cascade reaction for hypoxia mitigation and reactive oxygen species scavenging in wound healing.

"Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper."

"The authors graciously acknowledge support from the Cancer Scholars Program for XH, a 10.13039/100012211Carle Foundation Hospital and Cancer Center at Illinois initiative. Partial funding from the Health Maker Lab of the Carle Illinois College of Medicine and the Mikashi Award from the Institute of Genomic Biology, 10.13039/100005302University of Illinois at Urbana-Champaign is greatly appreciated. Thanks to Dr. Harley for providing us with the HUVEC cell line. We thank the TEP at Cancer Center at Illinois (UIUC) for assistance in biological evaluation. Our sincere thanks to Karen Doty at the Histology facility in the Department of Comparative Biosciences for the assistance in tissue processing and immunofluorescent staining. We thank Zunaira Shoaib for assistance in tissue analysis. Thanks to Dr. Tor Jensen for assistance in the animal studies. Xiaoxue Han: Writing – original draft, Methodology, Investigation, Formal analysis, Data curation, Conceptualization. Leah Ju: Writing – review & editing, Methodology. Chai Saengow: Data curation, Formal analysis, Methodology, Writing – review & editing. Wen Ren: Writing – original draft, Methodology, Formal analysis. Randy Ewoldt: Data curation, Formal analysis, Methodology, Visualization, Writing – review & editing. Timothy Fan: Writing – review & editing, Methodology. Joseph Irudayaraj: Writing – review & editing, Supervision, Resources, Project administration, Funding acquisition, Conceptualization."