Circulating microRNA expression and nonalcoholic fatty liver disease in adolescents with severe obesity.

"Conflict-of-interest statement: There are no conflicts of interest to report."

"Supported by National Institute of Environmental Health, No. R01ES030691; No. R01ES030364, No. R01ES029944, No. U01HG013288, No. T32-ES013678, No. P30ES007048, No. U2CES030859, No. R01ES032831, No. R01ES033688, No. P30ES023515, and No. P2CES033433; National Human Genome Research Institute and National Institute of Environmental Health, No. U01HG013288; California Environmental Protection Agency, No. 20-E0017; National Cancer Institute and National Institute of Environmental Health, No. P01CA196569; Ministry of Science and Innovation and State Research Agency, No. CEX2018-000806-S; European Union (“NextGenerationEU/PRTR”), No. IJC2020-043630-I; European Union’s Horizon Europe Research And Innovation Programme Under the Marie Skłodowska-Curie Actions Postdoctoral Fellowships, No. 101059245; United States Department of Agriculture, No. 6250-51000-053; National Institutes of Health, No. R01DK128117−01A1; and The Teen-LABS Consortium: National Institute of Diabetes and Digestive and Kidney Diseases, No. UM1DK072493 and No. UM1DK095710."

"This study was based on data from the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS study, ClinicalTrials.gov NCT00465829), a prospective, multicenter, observational study of adolescents (≤ 19 years of age) with severe obesity who underwent bariatric surgery in 2007-2012 and enrolled at participating clinical centers in the United States: Cincinnati Children’s Hospital Medical Center (Cincinnati, Ohio), Nationwide Children’s Hospital (Columbus, Ohio), University of Pittsburgh Medical Center (Pittsburgh, Pennsylvania), Texas Children’s Hospital (Houston, Texas), and Children’s Hospital of Alabama (Birmingham, Alabama)[,-]. The protocol, assent/consent forms, and monitoring plans for data and safety were approved by the institutional review boards of each institution, the independent data and safety monitoring board prior to study initiation, and the University of Southern California review board[,-]. Detailed cohort information is described in previous studies[,-]."