Substitution Models of Protein Evolution with Selection on Enzymatic Activity.

"data availability the data for building the sacs model the derived site-specific substitution rates matrices and amino frequencies at the equilibrium and the test data to evaluate the substitution models are available from zenodo repository at the url https://doi org/10 5281/zenodo 10559982 ."

"Funding: This work was supported by the Spanish Ministry of Science and Innovation through the grant (PID2019-107931GA-I00/AEI/10.13039/501100011033). D.F. was funded by a fellowship from the Xunta de Galicia (ED481A-2020/192). This work was also supported by Fundação para a Ciência e a Tecnologia (UIDP/04378/2020 and 2020.01423.CEECIND/CP1596/CT0003). Some calculations were performed with the Infraestrutura Nacional de Computação Distribuída (INCD), Portugal, funded by the FCT and FEDER under project 01/SAICT/2016 number 022153 and projects CPCA/A00/7140/2020 and CPCA/A00/7145/2020. Funding for open access charge: Universidade de Vigo/CISUG. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."

"Funding This work was supported by the Spanish Ministry of Science and Innovation through the grant (PID2019-107931GA-I00/AEI/10.13039/501100011033). D.F. was funded by a fellowship from the Xunta de Galicia (ED481A-2020/192). This work was also supported by Fundação para a Ciência e a Tecnologia (UIDP/04378/2020 and 2020.01423.CEECIND/CP1596/CT0003). Some calculations were performed with the Infraestrutura Nacional de Computação Distribuída (INCD), Portugal, funded by the FCT and FEDER under project 01/SAICT/2016 number 022153 and projects CPCA/A00/7140/2020 and CPCA/A00/7145/2020. Funding for open access charge: Universidade de Vigo/CISUG. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."