Distinct roles for type I and type III interferons in virulent human metapneumovirus pathogenesis.

"plos publication stage vor-update-to-uncorrected-proof publication update 2024-02-15 data availability genome sequence data has been submitted to genbank under the following accession numbers: pp086008 pp086535 pp086007 jn184400 pp086006 kc562242 kc562235 kc403972 jf929882.; data availability genome sequence data has been submitted to genbank under the following accession numbers: pp086008 pp086535 pp086007 jn184400 pp086006 kc562242 kc562235 kc403972 jf929882.; the sh and g genes were less conserved with amino acid identity even lower than nucleotide identity suggesting low selection pressure on these regions10 1371/journal ppat 1011840 t001 table 1 strain subgroup year of isolation site genbank a tn85-416 (42) a1 1985 nashville tn usa pp086008 tn94-344 (1501) a1 1994 nashville tn usa pp086535 tn94-711 (1509) a1 1994 nashville tn usa pp086007 tn/94-49 a2 1994 nashville tn usa jn184400 tn/94-66 a2 1994 nashville tn usa pp086006 c1-334 b1 2004 cincinnati oh usa kc562242 c2-202 b1 2004 cincinnati oh usa kc562235 tn/91-320 b2 1991 nashville tn usa kc403972 tn/96-35 b2 1996 nashville tn usa jf929882 a all sequences have now been submitted to genbank and the numbers are listed in the table. data availability genome sequence data has been submitted to genbank under the following accession numbers: pp086008"

"J.V.W. previously served on the Scientific Advisory Board of Quidel and an Independent Data Monitoring Committee for GlaxoSmithKline, neither activity involved with the work under consideration. All other authors declare no conflict of interest."

"This work was supported by NIH/NIAID grant R01 AI085062 to JVW. JVW was supported by the Henry L. Hillman Foundation. YZ received a Research Advisory Council (RAC) fellowship award from UPMC Children’s Hospital of Pittsburgh. YZ was supported by T32 AI089443. JX received scholarship from China Scholarship Council ([2016]3097). JS was supported by T32 GM008208. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."