Blood volume and hemodynamics during treatment of major hemorrhage with Ringer solution, 5% albumin, and 20% albumin: a single-center randomized controlled trial.

"Declarations Ethics approval and consent to participateThe study was approved by the Swiss government’s local ethics committee (cantonal ethics committee KEK Bern, Switzerland, KEKBE ID 2022-00209, chairperson Prof C. Seiler, May 11 2022); All patients gave preoperative written informed consent to participate Consent for publication. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding This study was supported by the institutional research funds of the Department of Anesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland, and an unrestricted award from CSL Behring, Bern, Switzerland."

"Trial registration : ClinicalTrials.gov NCT05391607, date of registration May 26, 2022."