PARD3 drives tumorigenesis through activating Sonic Hedgehog signalling in tumour-initiating cells in liver cancer.

"Declarations Protocols of all the animal studies were reviewed and approved by the Committee of Use of Laboratory Animal in Teaching and Research (CULATR) in the University of Hong Kong. Consent for publicationNot applicable. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding This research was partially supported by the Research Grants Committee (RGC) of Hong Kong, HKSAR (Project Codes: 17119621 and 17121419), the Health and Medical Research Fund (Project code: 18192141, 19200701 and 19201951), Innovation and Technology Fund (Project Code: PRP/028/22FX) and the Health@InnoHK Initiative Fund of the Hong Kong Special Administrative Region Government (Project Code: ITC RC/IHK/4/7)."