Cognitive, functional, and neuropsychiatric correlates of regional tau pathology in autopsy-confirmed chronic traumatic encephalopathy.

"Declarations Ethics approval and consent to participateInstitutional review board (IRB) approval for brain donation, post-mortem clinical record review, interviews with informants, and neuropathological evaluation were obtained through the Boston University Medical Campus (BUMC) IRB. Informed consent for brain donation and study enrollment was obtained from the brain donors’ next-of-kin. Consent for publicationNot applicable. Competing interestsDr. Goldstein is a paid consultant to Johnson & Johnson, Janssen Research & Development LLC, and Rebiscan Inc and has received funding from the WWE (World Wrestling Entertainment) and Ivivi Health Sciences.Dr. Nowinski is the Co-Founder and Chief Executive Officer of the Concussion Legacy Foundation, and serves as an advisor for Oxeia Biopharmaceuticals and PreCon Health, Inc.Dr. Stern is a paid consultant to Biogen, is a member of the Mackey-White Health and Safety Committee of the National Football League Players Association, receives royalties for published neuropsychological tests from Psychological Assessment Resources Inc, is a member of the Board of Directors of King-Devick Technologies, and reported grants from the National Institutes of Health during the conduct of the study.Dr. Cantu is a paid consultant to the National Football League Head Neck and Spine Committee, a vice president and chair of the scientific advisory committee of the National Operating Committee on Standards for Athletic Equipment, and a consultant to the Concussion Legacy Foundation; he also receives royalties from Houghton Mifflin Harcourt and compensation for expert legal opinion to the National Collegiate Athletic Association and National Hockey League and is a member of the Mackey-White Committee of the National Football League Players Association.Dr. McKee is a member of the Mackey-White Committee of the National Football League Players Association and reports receiving grants from the National Institutes of Health and Department of Veteran Affairs and other funding from Buoniconti Foundation during the conduct of the study.Dr. Alosco reported grants from National Institutes of Health during the conduct of the study.Dr. Katz reported grants from Boston University School of Medicine Department of Neurology during the conduct of the study, receives royalties from Springer/Demos Publishing for a text book on brain injury, serves as an expert witness in legal cases involving brain injury and concussion; receives a stipend from Encompass Health as program medical director for brain injury and chair of the annual Neurorehabilitation conference; has received honoraria for a keynote address for the HealthSouth annual Medical Directors meeting.Dr. Mez reported grants from the National Institutes of Health, Department of Defense, Alzheimer’s Association, and Concussion Legacy Foundation during the conduct of the study. Competing interests Dr. Goldstein is a paid consultant to Johnson & Johnson, Janssen Research & Development LLC, and Rebiscan Inc and has received funding from the WWE (World Wrestling Entertainment) and Ivivi Health Sciences. Dr. Nowinski is the Co-Founder and Chief Executive Officer of the Concussion Legacy Foundation, and serves as an advisor for Oxeia Biopharmaceuticals and PreCon Health, Inc. Dr. Stern is a paid consultant to Biogen, is a member of the Mackey-White Health and Safety Committee of the National Football League Players Association, receives royalties for published neuropsychological tests from Psychological Assessment Resources Inc, is a member of the Board of Directors of King-Devick Technologies, and reported grants from the National Institutes of Health during the conduct of the study. Dr. Cantu is a paid consultant to the National Football League Head Neck and Spine Committee, a vice president and chair of the scientific advisory committee of the National Operating Committee on Standards for Athletic Equipment, and a consultant to the Concussion Legacy Foundation; he also receives royalties from Houghton Mifflin Harcourt and compensation for expert legal opinion to the National Collegiate Athletic Association and National Hockey League and is a member of the Mackey-White Committee of the National Football League Players Association. Dr. McKee is a member of the Mackey-White Committee of the National Football League Players Association and reports receiving grants from the National Institutes of Health and Department of Veteran Affairs and other funding from Buoniconti Foundation during the conduct of the study. Dr. Alosco reported grants from National Institutes of Health during the conduct of the study. Dr. Katz reported grants from Boston University School of Medicine Department of Neurology during the conduct of the study, receives royalties from Springer/Demos Publishing for a text book on brain injury, serves as an expert witness in legal cases involving brain injury and concussion; receives a stipend from Encompass Health as program medical director for brain injury and chair of the annual Neurorehabilitation conference; has received honoraria for a keynote address for the HealthSouth annual Medical Directors meeting. Dr. Mez reported grants from the National Institutes of Health, Department of Defense, Alzheimer’s Association, and Concussion Legacy Foundation during the conduct of the study."

"Funding This work was supported by the National Institute of Neurological Disorders and Stroke (U01NS086659, U01NS093334, U54NS115266, R01NS078337, R56NS078337, K23NS102399), National Institute of Aging (P30AG13846; supplement 0572063345, R01AG057902, R01AG061028, K23AG046377, R01AG1649, R01AG062348, R21HD089088, F32NS096803, F32AG056098), National Center for Advancing Translational Sciences (1UL1TR001430), Department of Veterans Affairs (I01 CX001135, CSP 501, B6796-C, I01-CX001038), Department of Defense (W81XWH-13–2-0095, W81XWH-13–2-0064, W81XWH1810580, PRARP-13267017), the Alzheimer’s Association (NIRG-15–362697, NIRG-305779), the National Operating Committee on Standards for Athletic Equipment (NOCSAE), the Nick and Lynn Buoniconti Foundation, the Concussion Legacy Foundation, the Andlinger Foundation, the WWE, and the NFL."